1. Elucidation of the regulatory mechanism of ferroptosis and its involvement in various pathological conditions
Identification of the vitamin K-FSP1 pathway. (Mishima, Nature 2022)
Intracellular selenium transport by PRDX6 (Ito, Mishima, Conrad. Mol Cell 2024)
2. Therapeutic application and drug development targeting ferroptosis
New evaluation system for GPX4 enzyme activity (Nakamura, Ito, Mishima, Conrad. Cell Chem Biol 2024)
Regulation of cancer ferroptosis via inhibition of FSP1 by DHODH inhibitors (Mishima, Nature 2023)
3. Exploration of Novel Redox-Related Cell Death Pathways
Future research
Through these research efforts, we have developed extensive expertise in both in vitro and in vivo experimental and analytical systems for studying ferroptosis. We are also contributing, through international collaboration, to the authorship of a recommended review on ferroptosis research methodologies (Mishima, Nat Rev Mol Cell Biol, 2025).